|
Peritoneal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Two cases of malignant peritoneal mesothelioma without asbestos exposure: cytologic and immunohistochemical features.
|
22784439 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor also exhibited diffuse positivity for calretinin and p16, as well as partial positivity for WT1 (nuclear and cytoplasmic staining pattern) and D2-40.
|
27324529 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical stains performed on the cell block showed that the tumor cells were positive for calretinin and focally positive for pancytokeratin, CAM5.2, and smooth muscle myosin heavy chain.
|
31173483 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Calretinin expression was significantly associated with high (≥50) Ki-67 (P = 0.02), but not with parameters like age, tumor size, lymph node status, overall survival (OS), and disease-free survival.
|
28550498 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that calretinin is expressed by most undifferentiated colorectal adenocarcinomas, but only by a limited number of cells in well-differentiated tumors.
|
10366153 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
One hundred fourteen serous effusions from 71 patients with tumors and 43 patients with benign diseases were subjected to RT-PCR for expression of carcinoembryonic antigen (CEA), epithelial cell adhesion molecule (Ep-CAM), E-cadherin, mammaglobin, mucin 1 (MUC1) isoforms MUC1/REP, MUC1/Y, and MUC1/Z, calretinin, and Wilms' tumor 1 susceptibility gene.
|
16203775 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Calretinin (CR; <i>CALB2</i>) belonging to the family of EF-hand Ca<sup>2+</sup>-binding proteins (CaBP) is widely used as a positive marker for the identification of human malignant mesothelioma (MM) and functionally was suggested to play a critical role during carcinogenesis of this highly aggressive asbestos-associated neoplasm.
|
30545133 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High expression of tumour cell calretinin correlated with the epithelioid histotype and was also predictive of longer OS (P<0.001).
|
24594996 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It is also a prognostic marker since patients with tumors expressing high calretinin levels have better overall survival.
|
26848772 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, typical endometrioid glands, squamous differentiation, or an adenofibroma component are each present in 75% of these tumors whereas immunostains for calretinin and alpha-inhibin are negative.
|
15492758 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To systematically investigate the sensitivity of calretinin and D2-40 antibodies in epithelioid and sarcomatoid areas of malignant mesotheliomas, a tissue microarray with 341 malignant mesotheliomas, including 112 epithelioid, 46 sarcomatoid and 183 biphasic tumors was constructed.
|
17361207 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Constitutive calretinin downregulation decreases MM cells' growth and survival, and impairs tumor formation in vivo.
|
31671889 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunopositivity evaluation of calretinin and inhibin A was scored according to the percentage of staining intensity and the extent of positive cells, of ER alpha was scored based on the percentage of positive cells, and Ki67 score was recorded as the percentage of positively stained nuclei across the tumor, without taking in consideration the staining intensity.
|
29250651 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MM16 and MM35 cells slowly generated tumors at the site of subcutaneous inoculation in BALB/c-nude mice, but lost the expression of mesothelioma-related markers such as calretinin, D2-40 and Wilms' tumor 1 in the subcutaneous tumors.
|
21205078 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, CR downregulation via a lentiviral shRNA against CR (<i>CALB2</i>) resulted in a significantly reduced tumor formation <i>in vivo</i> in an orthotopic xenograft mouse model based on peritoneal MM cell injection.
|
30555628 |
2018 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
It is suggested that calretinin is active in the first steps of carcinogenesis in all human mesotheliomas and during several stages in the evolution towards malignancy.
|
11299732 |
2001 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Histological analysis of malignancy progression through immunohistochemical staining of the pleural, lymph node, and skin tissue revealed gradual loss of calretinin and gain of desmin, supporting a transformation from epithelioid to sarcomatoid tissue.
|
29059099 |
2018 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Cases negative for malignancy were 100% (50/50) positive for calretinin but negative for carcinoma markers.
|
31554354 |
2019 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In addition, serpin B5 and calretinin appear to be candidate biomarkers that may be accessible in patients for monitoring of cancer therapy with ease.
|
23151231 |
2013 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Depletion of CR led these cancer cell lines to enter apoptosis within 72 hr postinfection via strong activation of the intrinsic caspase 9-dependent pathway.
|
23595591 |
2013 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
MOC-31 and calretinin are of important clinical value for diagnosing and differentially diagnosing the cancer cells in pleural fluid of patients with lung cancer.
|
25346242 |
2015 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
However, a diagnosis of cancer after blood collection and bronchial asthma were associated with positive calretinin results.
|
29025836 |
2017 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Our results establish that CR-22k is detectable in the serum of cancer patients under specific pathological conditions.
|
9854474 |
1999 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
It is suggested that calretinin is active in the first steps of carcinogenesis in all human mesotheliomas and during several stages in the evolution towards malignancy.
|
11299732 |
2001 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
In addition, serpin B5 and calretinin appear to be candidate biomarkers that may be accessible in patients for monitoring of cancer therapy with ease.
|
23151231 |
2013 |